Fig. 4.

CP2 treatment reduces levels of human pTau in the brain tissue of male and female 3xTg-AD mice. A,C) Western blot analysis of protein expression in the brain tissue of vehicle- and CP2-treated female (A) and male (C) NTG and 3xTg-AD mice treated for 14 months. B,D) Changes in protein expression in CP2-treated NTG and 3xTg-AD female (B) and male (D) mice (from A and C, respectively) relative to the levels in vehicle-treated NTG counterparts. N= 4 –7 mice per group. E, F) Measurement of lipid peroxidation and oxidative stress in brain tissue of female (E) and male (F) 3xTg-AD mice showed trend towards reduced levels of malondialdehyde (MDA) in brain tissue. N= 4–9 mice per group. Differences between individual groups were analyzed by one-way ANOVA, with Fisher’s LSD post-hoc test. Data are presented as mean±SEM. ^*p < 0.05, ^**p < 0.01.