Fig. 2.

Glucocorticoids act through the glucocorticoid receptor (GR). GR activation promotes degradation of transcripts mediating proinflammatory signals through, among other mechanisms, RNA-binding proteins like tristetrapolin. GR activation also stimulates the expression of annexin A1 which serves to orchestrate termination of inflammation and avoid adverse prolonged activation. GR activation also acts directly to limit the action of key proinflammatory mediators.