Fig. 4.

Locus coeruleus-prefrontal cortex fibre tract-specific significant FDC decreases in patients with multiple sclerosis (RR-MS) compared to healthy control (HC). Tracts of interest projecting from locus coeruleus (LC) to medial and lateral orbitofrontal and dorsolateral prefrontal cortex (PFC) are shown in glass brain representations using the mrview tool in MRtrix3. Differences in average FDC between HC and RR-MS patients in the selected white matter tracts of the LC-PFC tracts are shown in scatter plots. Comparisons were tested by independent sample t-tests. The statistical threshold was set to p < 0.003 after Bonferroni correction for multiple comparisons (FDC = fibre-density cross-section, A = anterior, L = left, R = right).