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. 2021 Feb 12;30:102587. doi: 10.1016/j.nicl.2021.102587

Table 2.

Average values of fibre density (FD), fibre cross-section (FC), and fibre density and cross-section (FDC) in the selected fibre tracts in relapsing-remitting multiple sclerosis (RR-MS) patients and in healthy controls (HC). Data are reported as mean ± standard deviation. Statistical threshold was set to p < 0.003 after Bonferroni correction for multiple comparisons. *FC data are expressed as logarithm of FC values (logFC) to ensure that data were centred around zero and normally distributed.

Tract FD
 logFC*
 FDC
RR-MS HC p RR-MS HC p RR-MS HC p
VTA-Nacc 0.34 ± 0.02 0.36 ± 0.03 <0.0001 0.02 ± 0.08 0.09 ± 0.07 0.0001 0.35 ± 0.04 0.40 ± 0.06 <0.0001
VTA-amygdala 0.38 ± 0.02 0.40 ± 0.03 0.006 −0.01 ± 0.06 0.05 ± 0.06 <0.0001 0.39 ± 0.04 0.43 ± 0.06 <0.0001
VTA-hippocampus 0.32 ± 0.04 0.35 ± 0.03 0.0004 −0.01 ± 0.09 0.03 ± 0.07 0.07 0.31 ± 0.04 0.36 ± 0.04 <0.0001
VTA-dlPFC 0.33 ± 0.02 0.33 ± 0.01 0.83 0.04 ± 0.10 0.09 ± 0.10 0.06 0.35 ± 0.04 0.37 ± 0.05 0.07
VTA-mOfPFC 0.39 ± 0.02 0.39 ± 0.03 0.74 0.05 ± 0.09 0.10 ± 0.08 0.003 0.42 ± 0.05 0.45 ± 0.06 0.02
VTA-lOfPFC 0.41 ± 0.02 0.42 ± 0.03 0.07 0.04 ± 0.10 0.10 ± 0.09 0.003 0.43 ± 0.05 0.47 ± 0.07 0.003
LC-dlPFC 0.48 ± 0.02 0.49 ± 0.03 0.05 0.02 ± 0.09 0.08 ± 0.08 0.001 0.49 ± 0.06 0.54 ± 0.07 0.0009
LC-mOfPFC 0.49 ± 0.02 0.51 ± 0.03 0.0009 0.02 ± 0.08 0.10 ± 0.08 <0.0001 0.50 ± 0.06 0.57 ± 0.07 <0.0001
LC-lOfPFC 0.45 ± 0.02 0.46 ± 0.03 0.007 0.03 ± 0.08 0.09 ± 0.08 0.0001 0.46 ± 0.05 0.51 ± 0.06 <0.0001
MR-Cer Lob VII 0.38 ± 0.01 0.38 ± 0.02 0.42 0.10 ± 0.09 0.16 ± 0.10 0.007 0.42 ± 0.05 0.46 ± 0.06 0.001
MR-Cer Lob V + VI 0.35 ± 0.01 0.36 ± 0.01 0.06 0.06 ± 0.08 0.12 ± 0.08 0.001 0.39 ± 0.05 0.43 ± 0.05 0.0002
DR-Cer Lob VII 0.35 ± 0.02 0.35 ± 0.02 0.80 0.05 ± 0.08 0.10 ± 0.09 0.005 0.36 ± 0.04 0.39 ± 0.04 0.004
DR-Cer Lob V + VI 0.35 ± 0.02 0.35 ± 0.02 0.49 0.02 ± 0.07 0.08 ± 0.08 0.001 0.35 ± 0.03 0.38 ± 0.04 0.0004
Cingulum 0.34 ± 0.02 0.34 ± 0.02 0.07 0.01 ± 0.10 0.07 ± 0.09 0.005 0.35 ± 0.05 0.37 ± 0.05 0.08

[Abbreviations: VTA: ventral tegmental area; Nacc: nucleus accumbens; dlPFC: dorsolateral prefrontal cortex; mOfPFC: medial orbito-frontal prefrontal cortex; lOfPFC: lateral orbito-frontal prefrontal cortex; LC: locus coeruleus; Cer Lob: Cerebellar Lobule; MR: median raphe; DR: dorsal raphe].