Table 3.

Patient demographics and outcomes for infants born >34 weeks’ gestation admitted to neonatal units in England and treated with iNO

	2010–2011	2012–2013	2014–2015
Neonatal admissions requiring ≥1 day of intensive care (with and without iNO)	18 374	22 777	27 872
Infants treated with iNO	820 (4.5%*)	1015 (4.5%*)	1400 (5.0%*)
Birth weight (g)	3273 (2840,3665)	3240 (2760,3690)	3220* (2680,3630)
Gestational age (weeks)	40 (38,41)	39 (37,40)	39 (37,40)
Male sex	450 (54.9%)	577 (56.9%)	756 (54.0%)
Prolonged rupture of membranes >24 hours§	82 (10.0%)	92 (9.1%)	68 (4.9%)
Surfactant therapy in labour ward or neonatal unit	532 (64.9%)	613 (60.4%)	713 (50.9%)
Initiation of iNO therapy (days)	2 (1,2)	2 (1,2)	2 (1,2)
Duration of iNO therapy (days)	3 (2,5)	3 (2,5)	2 (1,5)
Diagnosis (not mutually exclusive)‡
Respiratory distress syndrome†	259 (31.6%)	378 (37.2%)	778 (55.6%)
Pulmonary hypoplasia	61 (7.4%)	67 (6.6%)	101 (7.2%)
Meconium aspiration syndrome	314 (38.3%)	378 (37.2%)	440 (31.4%)
Pulmonary hypertension	598 (72.9%)	703 (69.3%)	885 (63.2%)
Congenital pneumonia	42 (5.1%)	52 (5.1%)	74 (5.3%)
Congenital diaphragmatic hernia	55 (6.7%)	57 (5.6%)	83 (5.9%)
Death among infants who received iNO	165 (20.1%)	160 (15.8%)	212 (15.1%)

The denominator for all proportions is the number of babies treated with iNO unless indicated otherwise.

One baby with a birth weight less than 300 grams was removed from this calculation (n=1399).

*Denominator is all admissions to neonatal unit admissions requiring ≥1 day of intensive care. All values are given as n, % or median (25th,75th centiles) as appropriate.

†This includes the diagnosis respiratory distress syndrome and signs of respiratory distress of newborn (see online supplemental file 1).

‡Extracted codes available in online supplemental file.

§Prolonged rupture of membranes >24 hours uses a combination of discharge diagnoses and recorded duration of rupture of membranes.

iNO, inhaled nitric oxide.