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. 2020 Dec 16;11(4):1139–1161. doi: 10.1016/j.jcmgh.2020.12.007

Figure 4.

Figure 4

Relative distributions of pericentral and periportal landmark genes among all liver ECs as well as comparison of pathway analysis of periportal and pericentral LSECs. (A) Feature plots showing relative distributions of established pericentral landmark genes among all liver ECs. (B) Feature plots showing relative distributions of established periportal landmark genes among all liver ECs. (C) Comparison of signaling pathways enriched in zone 1 LSECs and zone 3 LSECs based on GSEA. The NES is the normalized enrichment score, which indicates the magnitude of the correlation of a gene set (signaling pathway) with the phenotype. A positive NES means upregulation in zone 1 LSECs relative to zone 3 LSECs, while a negative NES shows upregulation in zone 3 LSECs relative to zone 1 LSECs. The color represents a P value, which estimates statistical significance of the NES.