| Clinical features |
| Dry mouth. |
| Dry eyes. |
| Histopathology features |
| Lymphocytic infiltration in the lacrimal and/or salivary glands. |
| Destruction of the gland stroma and decreased acinar cell number. |
| Persistent lesion. |
| Serological features |
| Hypergammaglobulinemia |
| Anti-SSA |
| Anti-SSB |
| Anti-M3R (anti-muscarinic 3 receptor) |
| RF (rheumatoid factor). |
| Anti-CPP (anti-citrullinated cyclic peptide). |
| ACA (anti-centromere antibody). |
| AMA (anti-mitochondrial antibody. |
| Extra-glandular features |
| Multiple organs involvement including skin, respiratory system, liver, blood vessels etc. |
| Genetic features |
| Abnormal MHC I and II genes expression, especially HLA-DR and HLA-DQ. |
| Non-MHC-related genes: INF signaling pathway; B-cell activation and autoantibody production. |
