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. 2021 Feb 22;218(3):e20201798. doi: 10.1084/jem.20201798

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© 2021 Gao et al.

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Figure 1. — Distinct strains of influenza virus lead to different levels of DNA methylation and IFN-I induction. (A and B) Viral loads (A) and mRNA levels of Ifnb (B) induced by different influenza viruses (1 MOI for 6 h) in PBMCs from healthy donors (n = 32), as measured by qPCR. (C) Pyrosequencing results of the methylation levels in the whole genome of PBMCs from healthy donors infected with different influenza virus strains. (D) The expression of the indicated genes in PBMCs from healthy donors (n = 32) infected with different influenza viruses (1 MOI for 6 h) in vitro was measured by qPCR. The data from the qPCR assay are presented as fold changes relative to the actin mRNA levels. All data are representative of at least three independent experiments. The data are presented as means ± SEMs. The significance of differences was determined using a t test. *, P < 0.05; **, P < 0.01; ***, P < 0.005.