Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 22;218(3):e20201798. doi: 10.1084/jem.20201798

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Gao et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 4. — Uhrf1 does not affect canonical antiviral signal transduction. (A–E) The indicated proteins in cytoplasmic (CE) and nuclear (NE) extracts (A–C) or whole-cell lysates (D and E) of WT and Uhrf1-deficient BMDMs were measured by IB analysis. (F and G) Specific virus-induced phosphorylation of TBK1 and IRF3 in whole-cell lysates was measured by IB analysis. (H) IB analysis of monomeric and dimeric IRF3 (top blot), total IRF3, Uhrf1, and actin (bottom) in HEK293T cells transfected with empty vector or an expression plasmid for Uhrf1 and then infected with PR8 for various times. IB analysis of monomeric and dimeric IRF3 (top blot), total IRF3, Uhrf1, and actin (bottom) in HEK293T cells transfected with empty vector or an expression plasmid for Uhrf1 and then infected with PR8 for various times. All the data are representative of at least three independent experiments.