. 2021 Feb 16;5(4):1017–1028. doi: 10.1182/bloodadvances.2020003508

Table 2.

Molecular predictors of response

Genotype	No. of patients	CR rate, %	Univariable	Multivariable		ORR rate, %	Univariable	Multivariable
Genotype	No. of patients	CR rate, %	P	OR (95% CI)	P	ORR rate, %	P	OR (95% CI)	P
Total cohort	247	15				42.1
NGS result			.4				.22
No mutation	28	21.4				53.6
≥1 mutation	213	14.6				40.8
TET2			.09	2.80 (1.09-7.24)	.03^*		.08	1.92 (0.93-3.94)	.07
Mut	41	24.3				56.1
WT	188	12.8				40.4
ASXL1			.02^*	0.13 (0.02-1.08)	.06		.07	0.49 (0.22-1.08)	.08
Mut	47	4.3				29.8
WT	200	17.5				45.0
TET2-mut/ASXL1-WT			.004^*	3.15 (1.20-8.30)	.02^*		.03^*	1.99 (0.86-4.59)	.10
Present	29	34.5				62.1
Other	206	12.1				39.8
DNMT3A			.31				.85
Mut	35	8.6				45.7
WT	193	16.1				43.0
EZH2			>.99				.59
Mut	15	13.3				33.3
WT	232	15.1				42.7
DNA methylation mutation			.7				.33
Mut	79	16.5				48.1
WT	148	14.2				41.2
Epigenetic regulation			.47				.36
Mut	120	13.3				40
WT	115	17.4				46.1
SF3B1			.7				.4
Mut	13	7.7				30.8
WT	217	15.7				44.2
Any spliceosome			.048^*	0.46 (0.16-1.33)	.15		.57	0.86 (0.46-1.63)	.65
Mut	77	7.8				40.3
WT	152	18.4				44.7
RUNX1			>.99				>.99
Mut	24	12.5				41.7
WT	223	15.2				42.2
Signaling pathway			.18				.57
Mut	32	6.3				37.5
WT	196	16.3				44.4
TP53			.08	1.29 (0.56-3.0)	.55		.79	1.01 (0.54-1.89)	.96
Mut	82	20.7				43.9
WT	165	12.1				41.2

Response rates among the total cohort stratified by genotype; multivariable analysis was performed using a binary logistic-regression model (ORR defined as CR + mCR + PR + HI).

CI, confidence interval; OR, odds ratio.

Denotes statistical significance (P < .05).