Table 2.

Key brain regions with at least 2 structural studies associated with anosognosia or metacognition

Region	N of MRI studies
Frontal	Anosognosia	Metacognition	Both	Total studies
Inferior frontal Gyrus		1↓	1↓	2↓
Superior frontal Gyrus	1↓	1↓	2↓	4↓
Middle/medial frontal Gyrus		1↓	1↓	2↓
Prefrontal cortex (PFC)
Orbitofrontal		1↓	2↓	3↓
Medial PFC (mPFC)		1↓	1↓	2↓
Temporal
Medial temporal lobe		1↓	1↓	2↓
Cingulate cortex
Anterior cingulate cortex	1↓		2↓	3↓
Posterior cingulate cortex		2↓		2↓
Insular
Insula		1↓	1↓	2↓

Key: MRI, magnetic resonance imaging.

↓ = negative correlation—as anosognosia/metacognition scores worsen, gray matter volume/density decreases.