Table 5.

Brain regions with at least 2 structural and 2 functional studies correlating with anosognosia

Region	N of structural studies				N of functional studies
Frontal	A	M	B	T	A	M	B	T
Inferior frontal Gyrus		1	1	2↓	5	1	1	7↓
Superior frontal Gyrus	1	1	2	4↓	2		1	3↓
Middle/medial frontal Gyrus		1	1	2↓		1	1	2↓
Prefrontal cortex (PFC)
Orbitofrontal		1	2	3↓	2		2	4↓✝
Temporal
Medial temporal lobe		1	1	2↓	2		2	4↓
Cingulate cortex
Anterior cingulate cortex	1		2	3↓	3		2	5↓
Posterior cingulate cortex		2		2↓	1		2	3↓/↑✝
Insular
Insula		1	1	2↓	1		1	2↓

A, anosognosia study, M, Metacognition study, B, Study using both anosognosia and metacognition measures, T, Total N of studies.

↓ = negative—decreased blood flow/glucose metabolism associated with worse anosognosia/metacognition scores.

↑ = positive correlation—increased blood flow/glucose metabolism associated with worse anosognosia/metacognition score.

✝ Perrotin et al. (2015) found significance across FDG-PET & fMRI.