Table 2.
Treatments and outcomes of the patients in the Sichuan and Wuhan cohorts
| Variable | Total | Sichuan cohort | Wuhan cohort | χ2/Z | P value |
|---|---|---|---|---|---|
| n | 1184 | 474 | 710 | ||
| Treatments, n (%) | |||||
| Antiviral treatment | 1110 (93.8) | 448 (94.7) | 662 (93.2) | 1.067 | 0.302 |
| Antibiotics | 698 (59.0) | 204 (43.0) | 494 (69.6) | 82.734 | < 0.001 |
| Antifungal treatment | 35 (3.0) | 15 (3.2) | 20 (2.8) | 0.120 | 0.729 |
| Corticosteroids | 272 (23.0) | 63 (13.3) | 209 (29.4) | 41.872 | < 0.001 |
| Intravenous immunoglobin | 9 (0.8) | 3 (0.6) | 6 (0.8) | 0.170 | 0.680 |
| Oxygen therapy | 791 (66.9) | 273 (57.7) | 518 (731) | 30.175 | < 0.001 |
| Prone-position ventilation | 30 (2.5) | 22 (4.6) | 8 (1.1) | 14.217 | < 0.001 |
| Tracheotomy | 8 (0.7) | 4 (0.8) | 4 (0.6) | 0.720* | |
| ECMO | 3 (0.3) | 1 (0.2) | 2 (0.3) | 1.000* | |
| Renal replacement | 9 (0.8) | 5 (1.1) | 4 (0.6) | 0.497* | |
| Blood transfusion | 165 (14.0) | 30 (6.3) | 135 (19.1) | 38.587 | < 0.001 |
| Nutrition support | 131 (11.1) | 52 (11.0) | 79 (11.2) | 0.014 | 0.906 |
| TCM treatments | 912 (77.0) | 418 (88.2) | 494 (69.6) | 55.620 | < 0.001 |
| Physiotherapy | 29 (2.4) | 24 (5.1) | 5 (0.7) | 22.605 | < 0.001 |
| Outcomes | |||||
| Death, n (%) | 62 (5.2) | 3 (0.6) | 59 (8.3) | 33.758 | < 0.001 |
| ICU admission, n (%) | 127 (10.7) | 30 (6.3) | 97 (13.7) | 15.961 | < 0.001 |
| Noninvasive mechanical ventilation, n (%) | 69 (5.8) | 27 (5.7) | 42 (5.9) | 0.025 | 0.875 |
| Invasive mechanical ventilation, n (%) | 18 (1.5) | 8 (1.7) | 10 (1.4) | 0.148 | 0.700 |
| Time from illness onset to hospitalization, days | 8.00 (4.00,13.00) | 5.00 (2.00,9.00) | 10.00 (7.00,15.00) | 13.626 | < 0.001 |
| Hospital stay, days | 16.00 (9.00,24.00) | 17.00 (12.00,24.00) | 14.00 (9.00, 24.00) | −2.726 | < 0.001 |
| Time from illness onset to ICU admission, days | 9.00 (6.00,17.00) | 7.00 (4.00,10.50) | 11.50 (8.75,24.25) | 3.192a | < 0.001 |
| Time from hospitalization to ICU admission, days | 3.00 (0.00,9.00) | 4.00 (0.00,9.00) | 3.00 (0.00,10.50) | 0.415 | 0.678 |
| Time from illness onset to discharge, days | 26.00 (18.00,35.00) | 23.00 (18.00,31.00) | 28.00 (18.00,38.00) | 5.693 | < 0.001 |
| Time from illness onset to death, days | 16.50 (13.00,21.75) | 13.00 (11, −) | 17.00 (13.00,23.50) | 1.240a | 0.235 |
| Time from hospital admission to death, days | 5.00 (3.00,7.00) | 10.00 (6.00,-) | 4.00 (3.00,7.00) | 1.427 | 0.153 |
| Duration of viral shedding, days | 14.00 (9.00, 22.00) | 13.00 (8.00,18.00) | 17.00 (11.00,27.00) | 6.665 | < 0.001 |
* Fisher’s exact test
ECMO Extracorporeal membrane oxygenation, TCM Traditional Chinese medicine