Table I.
Characteristics of all datasets included in the quantitative synthesis.
| First author | Year | Ethnicity | Genotyping method | Sample size (cases/controls) | Variant | NOS score | Refs. |
|---|---|---|---|---|---|---|---|
| Jonsson | 2013 | Caucasian | Assay, Taqman | 2037/9727 | R47H | 9 | (4) |
| Guerreiro (discovery) | 2013 | Caucasian | NGS, Sequencing | 1091/1105 | R47H, R62H, D87N, H157Y | 9 | (8) |
| Guerreiro (replication) | 2013 | Caucasian | Taqman | 1887/4061 | R47H | 9 | (8) |
| Pottier | 2013 | Caucasian | Sequencing | 726/783 | R47H, R62H, D87N | 7 | (27) |
| Bertitez | 2013 | Caucasian | Sequencing | 504/550 | R47H, R62H, D87N | 7 | (28) |
| Gonzalez | 2013 | Caucasian | Taqman | 427/2540 | R47H | 7 | (29) |
| Ruiz | 2014 | Caucasian | Taqman, HRM, KASPar | 3172/2169 | R47H | 8 | (30) |
| Cuyvers | 2014 | Caucasian | Sequencing | 1216/1094 | R47H, R62H, D87N, H157Y | 7 | (31) |
| Miyashita | 2014 | Asian | Taqman | 2190/2498 | R47H, H157Y | 8 | (10) |
| Jin | 2014 | Caucasian | Taqman | 2082/1648 | R47H, R62H, D87N, H157Y | 7 | (11) |
| Slattery | 2014 | Caucasian | Sequencing | 971/534 | R47H, R62H, D87N | 8 | (32) |
| Finelli | 2015 | Caucasian | Sequencing | 474/608 | R47H | 7 | (33) |
| Roussos | 2015 | Caucasian | Sequencing | 265/225 | R47H | 7 | (34) |
| Jin | 2015 | African | Sequencing | 906/2487 | R47H, R62H, D87N, H157Y | 8 | (9) |
| Mehrjoo | 2015 | Caucasian | Sequencing | 131/157 | R47H, R62H | 7 | (14) |
| Rosenthal | 2015 | Caucasian | Taqman | 1613/2927 | R47H | 8 | (35) |
| Jiang | 2016 | Asian | NGS | 988/1354 | H157Y | 8 | (12) |
| Ghani | 2016 | Caucasian | NGS | 210/233 | R47H, D87N, H157Y | 7 | (36) |
| Sirkis (discovery) | 2016 | Caucasian | NGS | 31/245 | R47H, D87N | 7 | (26) |
| Sirkis (replication) | 2016 | Caucasian | NGS | 2927/2633 | R47H, D87N, H157Y | 8 | (26) |
| Bellenguez | 2017 | Caucasian | NGS | 1779/1273 | R47H | 8 | (37) |
| Peplonska | 2018 | Caucasian | Sequencing | 274/208 | R47H, R62H, D87N | 7 | (15) |
| Landoulsi | 2018 | African | Sequencing | 172/158 | R62H | 7 | (38) |
| Arboleda-Bustos | 2018 | Caucasian | KASPar | 358/329 | R47H, R62H | 7 | (16) |
| Dalmasso | 2019 | Mixed | Taqman | 419/486 | R47H, R62H | 7 | (39) |
| Ayer | 2019 | Mixed | Taqman | 1157/5089 | R47H | 8 | (40) |
HRM, high-resolution melting; KASPar, KBioscience competitive allele-specific polymerase chain reaction genotyping system; NGS, next-generation sequencing; NOS: Newcastle-Ottawa Scale.