Table I.
Changes in physical and metabolic parameters in rats.
| Baseline | 4 weeks | 8 weeks | 12 weeks | 16 weeks | 20 weeks | 24 weeks | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | Normal diet | High-fat diet | Normal diet | High-fat diet | Normal diet | High-fat diet | Normal diet | High-fat diet | Normal diet | High-fat diet | Normal diet | High-fat diet | Normal diet | High-fat diet |
| Weight (g) | 241.20±17.04 | 238.71±18.53 | 318.52±34.51 | 315.47±43.48 | 363.08±42.20 | 418.18±63.49a | 377.05±62.27 | 463.75±68.38b | 410.09±59.33 | 528.59±92.26b | 429.76±64.29 | 585.69±83.05b | 453.86±57.22 | 614.00±121.83b |
| Body length (cm) | 20.97±1.34 | 20.73±0.96 | 22.4±1.24 | 22.18±1.73 | 23.39±1.05 | 23.89±1.41 | 24.70±1.09 | 24.04±1.68 | 24.35±1.27 | 24.95±1.25 | 24.57±1.40 | 25.88±1.30 | 25.76±0.89 | 25.43±2.30 |
| Abdominal circumference (cm) | 16.20±0.63 | 16.36±0.85 | 17.85±1.23 | 18.18±0.97 | 18.35±0.75 | 19.24±0.71b | 18.05±1.14 | 19.82±1.01b | 19.00±2.21 | 20.92±1.88a | 20.07±1.17 | 21.75±1.60a | 21.21±0.91 | 23.14±1.07b |
| Lee's index | 297.59±17.00 | 299.54±12.41 | 304.91±10.61 | 307.18±13.83 | 304.65±4.25 | 312.41±6.15b | 306.80±39.29 | 321.80±10.62 | 304.79±16.39 | 322.98±13.93a | 306.68±12.08 | 322.89±11.23a | 303.89±11.62 | 333.90±17.32b |
| HR (bpm) | 377.9±24.55 | 362.43±13.52 | / | / | 371.80±42.37 | 406.29±45.82 | 372.60±29.95 | 375.21±46.00 | 365.80±66.99 | 399.25±30.38 | 386.71±37.66 | 397.50±43.82 | 401.5±42.95 | 413.71±26.65 |
| SBP (mmHg) | 116.40±9.79 | 113.14±7.12 | / | / | 117.90±13.54 | 126.00±16.30 | 120.80±6.88 | 138.21±14.43b | 106.00±15.98 | 141.17±21.61b | 112.57±13.11 | 142.33±26.29b | 102.33±24.65 | 145.00±17.17b |
| DBP (mmHg) | 76.60±5.35 | 69.57±7.56a | / | / | 86.50±11.92 | 89.64±17.93 | 77.70±11.00 | 104.36±15.44b | 75.10±16.48 | 106.50±22.37b | 74.29±10.77 | 98.33±11.71b | 74.83±11.97 | 92.43±20.25a |
| TG (mmol/l) | 0.38±0.16 | 0.39±0.09 | / | / | 1.43±0.59 | 1.04±0.87 | / | / | 1.46±0.32 | 2.02±0.51 | / | / | 1.53±0.39 | 1.44±0.63 |
| TC (mmol/l) | 1.79±0.31 | 1.71±0.44 | / | / | 1.69±0.14 | 2.21±0.33b | / | / | 1.51±0.36 | 2.02±0.47 | / | / | 1.57±0.44 | 2.31±0.45a |
| HDL-C (mmol/l) | 0.94±0.13 | 0.96±0.31 | / | / | 0.86±0.09 | 0.85±0.23 | / | / | 0.99±0.18 | 0.97±0.22 | / | / | 0.96±0.24 | 1.05±0.33 |
| LDL-C (mmol/l) | 0.68±0.09 | 0.67±0.20 | / | / | 0.69±0.21 | 0.72±0.30 | / | / | 0.67±0.09 | 0.89±0.09a | / | / | 0.81±0.23 | 0.61±0.46 |
| FBG (mmol/l) | 4.98±0.44 | 4.66±0.63 | / | / | 4.83±0.44 | 5.13±0.39 | / | / | 5.32±0.56 | 4.84±0.20 | / | / | 4.97±0.36 | 5.55±0.58 |
| INS (µU/ml) | 0.11±0.06 | 0.13±0.17 | / | / | 0.19±0.13 | 0.17±0.14 | / | / | 0.14±0.05 | 0.12±0.04 | / | / | 0.08±0.03 | 0.19±0.09a |
aP<0.05,
bP<0.01 vs. normal diet group. HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglyceride; TC, total cholesterol; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; FBG, fasting blood glucose; INS, insulin; bpm, beats per minute.