Table 2.

Main results of the identified lead SNPs in bivariate GWAS meta-analyses

LBM Site	Marker	Chr	Position	Locus	A1/A0	EAF	Discovery					Replication
							BMD		LBM		Bivariate	BMD		LBM/LBMadj		Bivariate
							Beta (SE)	P	Beta (SE)	P	P	Beta (SE)	P	Beta (SE)	P	P
Arm, unadjusted	rs61540635	2	29,047,358	2p23.2	W/M	0.54	−0.037 (0.015)	1.13 × 10−6	− 0.060 (0.015)	6.33 × 10−5	1.27 × 10−8	–	–	–	–	–
	rs4477866*	2	29,009,089	2p23.2	C/A	0.43	0.077 (0.014)	3.80 × 10−8	0.045 (0.015)	2.70 × 10−3	3.47 × 10−8	0.018(0.003)	2.00 × 10−13	0.009 (0.002)	1.20 × 10−5	1.03 × 10−4
Leg, unadjusted	rs 1421085	16	53,800,954	16q 12.2	T/C	0.59	− 0.042 (0.014)	2.70 × 10−3	− 0.083 (0.014)	3.06 × 10−9	2.04 × 10−9	− 0.019 (0.003)	6.40 × 10−15	− 0.078 (0.002)	1.20 × 10−338	6.47 × 10−14
	rsl 1152213	18	57,852,948	18q21.32	C/A	0.25	0.039 (0.015)	9.32 × 10−3	0.086 (0.015)	9.85 × 10−9	3.47 × 10−8	0.014(0.003)	5.50 × 10−7	0.060 (0.002)	1.30 × 10−150	6.69 × 10−6

Chr chromosome, A1 effect allele. Allele frequencies (EAF) are reported for the A1 allele. Beta regression coefficient, SE the standard deviation of beta, P the p value calculated in meta-analysis

^*Represents the proxy SNP