Figure 6.

Display of the murine wedge (3VQ2, 5IJD; Δ in Table 1). The surfaces of the amino acids are colour coded by their electrostatic properties (red: anionic/acidic; blue: cationic/basic; and white: non-polar/hydrophobic). The three cycles locate the sites which interact with the two phosphate groups on the diglucosamine scaffold of LPS-like ligands. Two combinations have been crystallographic observed: PagPan (yellow) and Pag (black) occupied by both phosphate groups of agonists; or PagPan and Pan (green) for phosphate groups of antagonists. It can be seen that the Pan site is a very unfavourable place for anions.