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. 2021 Feb 24;16(Suppl 1):352. doi: 10.1186/s13023-020-01620-4
Properties Name Molecules Dose Max. dose Precautions Duration Action
Antalgic
Gel Pansoral ointment or gel® Choline chloride salicylate of cetalkonium 1–4 application/day 4/day Children > 6 years, allergy to salicylates 5 days Antalgic antiseptic—Attention: alcohol content
Aftagel® Zinc sulfate, lidocaine 1 application to be repeated, if necessary 2 applications/day 5 days Antalgic, antiseptic
Pyralvex® gel Root of oxalic salicylic acid 4 applications/day 4 applications/day Children > 6 years, allergy to salicylates 5 days Anti-inflammatory, antalgic
Gingival solution Pyralvex® solution Root of oxalic salicylic acid 4 applications/day 4 applications/day Children > 6 years, allergy to salicylates 5 days Anti-inflammatory, antalgic
Cp Aphthoral® Chlorhexidine tetracaine and ascorbic acid

Child: 6-15 years 1 cp to be sucked, to be repeated at the end of 2 h

Adult: 1 cp to be sucked, to be repeated at the end of 2 h

3 cp/day for the child and 4 cp/day for the adult Child > 6 years. To be taken apart from meals or beverages. CI for pregnant or nursing women for aphthoral 5 days Antiseptic with local anesthetic—trophic action on the conjunctive tissue
Drill® Chlorhexidine Tetracaine Antiseptic with local anesthetic
Lysopaine® Lysozymes Cetylpiridinium 1 cp to be sucked, to be repeated at the end of 2 h 6 cp/day > 6 years 5 days Natural antiseptic and antibacterial
Protector/healing agent
Gel Bloxaphtha® gel junior or adult Hyaluronic acid 3 applications/day 3 applications/day Children > 30 months 5 days Anti-inflammatory, anti-edematous, healing agent
Borostyrol® gel Hyaluronic acid 3 applications/day 3 applications/day Children > 36 months 5 days Anti-inflammatory, anti-edematous, healing agent
Hyalugel® adult/Ado Hyaluronic acid 5 applications/day 5 applications/day Children > 30 months for the gel Ado 5 days Anti-inflammatory, anti-edematous, healing agent
Gingival solution Urgo aphtha filmogen® Cellulosic derivatives, carboxylic acid, mineral acid 1 application before meals 4 x/day Child > 6 years and CI pregnant women 5 days Antalgic, healing agent, protection
cp Lyso-6® Lysozymes pyridoxine 1 cp to be sucked, to be repeated at the end of 1 h 8 cp/day > 6 years CI if treatment by levodopa 5 days Natural antibacterial and healing agent
Local treatments
1st line ULCAR 1 g® suspension drinkable in packets Sucralfate 5 ml × 4/day (2 packets in 1 glass of water, while gargling 4 times per day (after meals), then spit out, or place directly on the lesions) 4 ×/day > 14 years 5 days Topical protective action
2nd line (if aphthosis severe) Corticosteroids or NSAIDs Betneval 0.1 mg buccal® Betamethasone Slowly suck the tablets, without chewing or swallowing, up to complete disintegration 5–10/day > 6 years. Mouthwashes. Do not swallow Several days Anti-inflammatory
Dermoval® Clobetasol propionate Prompt application on the buccal mucous > 6 years. Do not swallow Several days Anti-inflammatory
Solupred® effervescent Prednisolone Adult 60 mg child 15 mg in 250 ml of EPPI 3–4 ×/day > 6 years. Mouthwashes. Do not swallow Several days Anti-inflammatory
Aspegic Acetylsalicylic acid 1 g 1 packet in 1/2 glass of water > 6 years. Mouthwashes. Do not swallow Several days Anti-inflammatory