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. 2021 Feb 23;40:79. doi: 10.1186/s13046-021-01875-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Decision Curve Analysis of the 2-miRs model in the Validation cohort 2. a. Roc model 2-miRs based according to cancer status in validation cohort 2. b. Decision curve analysis for the 2-miR model based according to cancer status in validation cohort 2. The straight red line at y = 0 represents a strategy of performing a biopsy in no patients and the blue line represents the strategy of performing a biopsy in all patietns. The area of the graph for which a risk calculator has a greater net benefit than both the ‘biopsy none’ and ‘biopsy all lines is where it has greatest clinical applicability. c. Roc model 2-miRs based according to High grade tumor status in validation cohort 2. d. Decision curve analysis for the 2-miRs model based according to grade tumor status in validation cohort 2. The straight red line at y = 0 represents a strategy of performing a biopsy in no patients and the blue line represents the strategy of performing a biopsy in all patietns. The area of the graph for which a risk calculator has a greater net benefit than both the ‘biopsy none’ and ‘biopsy all lines is where it has greatest clinical applicability