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. 2021 Feb 24;19:26. doi: 10.1186/s12964-020-00697-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Microarray profiling of D7 TCQA-treated versus D0 control hAECs. a Scatter plot showing the DEGs. X-axis represents the average signal intensities (log2) in D0 control. Y-axis represents the average signal intensities (log2) in D7 TCQA-treated hAECs. The red color represents the upregulated DEGs, green color represents the downregulated DEGs, and grey color represents the nonsignificant genes. b Significantly enriched GOs by upregulated (analyzed using GSEA). c Significantly enriched KEGG pathways by upregulated DEGs (analyzed using DAVID and GSEA). d Significantly enriched GOs by downregulated (analyzed using GSEA). e Top significantly enriched KEGG pathways by the downregulated DEGs (analyzed using DAVID and GSEA). Each bar is arranged according to significance (p-values) and represents the number of DEGs