Table 2.

Top downregulated genes in D7 TCQA-treated hAECs (vs D7 control) *

Gene symbol	Gene name	Biological function	Fold-change	P value**
TNFα	Tumor necrosis factor alpha	Inflammatory response; Cell activation; Cell death; Negative regulation of apoptotic process	− 3.65	0.004
IL6	Interleukin 6	Negative regulation of collagen biosynthesis; Inflammatory response; Cytokine response	− 3.32	0.009
IL8	Interleukin 8	Pro-inflammatory response; Angiogenesis; Phagocytose	− 2.88	0.016
FOS	FBJ osteosarcoma oncogene	Cyclin D1 activation; Cell cycle regulation	− 2.80	0.001
ABCG1	ATP-binding cassette transporter G1	Cholesterol accumulation; T cell homeostasis alteration	− 2.65	0.045
PTGS2	Prostaglandin G/H synthase 2	Production of inflammatory prostaglandins; Cell adhesion; Resistance to apoptosis; Tumor angiogenesis	− 2.65	0.033
SORT1	Sortilin	Neuronal apoptosis: Coronary artery disease; Tumor cell survival	− 2.45	0.012
GPNMB	Glycoprotein non-metastatic melanoma protein B	Alzheimer disease marker; Regulator of melanoma tumor growth	− 2.43	0.004
IRF2	Interferon regulatory factor 2	Oncogene; Human leukaemia cell growth	− 2.24	0.001
KLK6	Kallikrein-6	Pathogenesis of Parkinson disease; Collagen and filament degradation	− 2.22	0.023
TRPV3	Transient receptor potential cation channel subfamily V member 3	Negative regulator of hair growth and cycling; Suppresses keratinocyte proliferation	− 2.17	0.043
IFNLR1	Interferon, lambda receptor 1	Inflammatory and cytokine response	− 2.12	0.002

*Genes functions were obtained from NCBI. **ANOVA was performed to assess the level of significance between groups