Table 2.

Number of Systematic Reviews and Meta-Analyses Evaluating the Effect of Periodontal Treatment on Systemic Disease That Did Not Meet AMSTAR 2 Critical Domains (n = 52).

AMSTAR 2 Critical Domains	Criteria Not Met, n (%)
Protocol registered before commencement of the review (item 2)	41 (78.8)
Justification for excluding individual studies (item 7)	26 (50.0)
Assessment of presence and likely impact of publication bias (item 15)	21 (40.4)
Risk of bias from individual studies being included in the review (item 9)	18 (34.0)
Appropriateness of meta-analytical methods (item 11)	18 (34.0)
Consideration of risk of bias when interpreting the results of the review (item 13)	16 (30.8)
Adequacy of the literature search (item 4)	6 (11.5)

AMSTAR 2, A MeaSurement Tool to Access systematic Reviews 2 (Shea et al. 2017).