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. Author manuscript; available in PMC: 2021 Feb 24.
Published in final edited form as: Ann Neurol. 2020 Nov 7;89(2):254–265. doi: 10.1002/ana.25948

Figure 1. Our hypothesized mechanism of mediation.

Figure 1.

We aimed to test whether socioeconomic status (Area Deprivation Index [ADI]) or any of three small vessel and cardiovascular-related disease factors have a mediating impact of the effect of race on the AT(N) measures used throughout the analyses. In addition to forcing the four hypothesized mediators into the same model, we allowed for the consideration of four other key covariates—age, APOE ε4 status, sex, and polygenic risk score (PRS)—as possible mediators of the direct race effect.

WMH = white matter hyperintensities; BP = blood pressure; BMI = body mass index; rs-fc = resting state functional connectivity; AD = Alzheimer’s disease