. Author manuscript; available in PMC: 2021 Feb 24.

Published in final edited form as: Ann Neurol. 2020 Nov 7;89(2):254–265. doi: 10.1002/ana.25948

Table 2.

Mediation analysis results for Alzheimer Disease (AD) volume signature.

AD Volume Signature
Total Effect	0.265	(0.051)
Direct Effect	0.234	(0.052)
Indirect Effect	0.032	(0.024)
Indirect Effect Components
ADI	0.031	(0.024)
BMI	−0.008	(0.009)
Systolic BP	0.004	(0.004)
WMH	0.004	(0.010)
Age	N/A	N/A
Sex	−0.001	(0.003)
APOE ε4 Status	N/A	N/A

Note. ADI = Area Deprivation Index; BP = blood pressure; WMH = white matter hyperintensities; APOE ε4 = APOE ε4; PRS = polygenic risk score

For multiple mediation analysis, race served as the direct effect. ADI, BMI, BP, and WMH were the indirect effects tested in a combined model. Age, sex, APOE ε4 status, and PRS were included in the final model.