Table 3.

Mediation analysis results relying on years of education as a proxy for socioeconomic status (SES).

AD Volume Signature
Total Effect	−0.236	(0.063)
Direct Effect	−0.235	(0.059)
Indirect Effect	−0.001	(0.015)
Indirect Effect Components
Years Education	−0.002	(0.004)
BMI	0.011	(0.009)
Systolic BP	−0.002	(0.004)
WMH	−0.006	(0.010)
Age	N/A	N/A
Sex	−0.002	(0.004)
APOE ε4 Status	N/A	N/A

Note. ADI = Area Deprivation Index; BP = blood pressure; WMH = white matter hyperintensities; APOE ε4 = APOE ε4; PRS = polygenic risk score

For multiple mediation analysis, race served as the direct effect. Education, BMI, BP, and WMH were the indirect effects tested in a combined model. Age, sex, APOE ε4 status, and PRS were included in the final model.