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. 2021 Feb 19;14(2):dmm046953. doi: 10.1242/dmm.046953

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — B6 background is most susceptible, whereas 129 background is most resistant, to ocular disease phenotypes. (A) At 3-5 months, B6 mice have the most severe anterior chamber deepening (ACD), even compared to D2-G mutants (P=0.0034). Strain 129 mutants rarely develop abnormal ACD at any age. ACD is a symptom of intraocular pressure (IOP) elevation. (B-D) The same trends were observed for corneal haze, and pupillary and corneal abnormalities. *P<0.01; **P<1.0×10^–5; ***P<1.0×10^–10 (Fisher's exact test; see Table S1 for exact P-values).