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. 2021 Feb 24;9(4):e14480. doi: 10.14814/phy2.14480

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© 2021 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Compartmental model of saturated fatty acid (SFA) and polyunsaturated fatty acid (PUFA) hepatic kinetics. (a) The linoleic acid (LA) model was used to calculate hepatic clearance (HC) and VLDL incorporation (VLDL‐i) of PUFA. Compartment 1 and 4 represent nonesterified fatty acids in perfusate. Compartment 1 was included in the model as a forcing function (FF). Compartment 2 and 5 represent processing in the liver; and compartment 3 and 6 represent fatty acids in VLDL. (b) LPS suppresses hepatic clearance (HC) of linoleic acid (LA), but HC of palmitic acid (PA) was unchanged with treatment. Soluble epoxide hydrolase inhibition (sEHi) had no effect on HC