Table 1.
Participant Characteristics
| OC (N = 69) | ITT-LOCF (N = 100) | P value | ||||
|---|---|---|---|---|---|---|
| Mean | Std. Deviation | Mean | Std. Deviation | T-Statistic (DF) | ||
| Age | 74.38 | 6.98 | – | – | – | – |
| Males (%) | 48 (48%) | – | – | – | – | – |
| Body weight (kg) | 59 | 11.48 | ||||
| Blood pressure – Systolic | 137.45 | 19.09 | ||||
| Blood pressure – diastolic | 71.03 | 12.13 | ||||
| Heart rate (beats per min) | 67.52 | 10.25 | ||||
| Years of education | 7.58 | 4.64 | – | – | – | – |
| Fazekas Score | 2.23 | 0.42 | – | – | – | – |
| MMSE | ||||||
| Baseline (OC N=99) | 21.45 | 4.48 | 21.52 | 4.45 | 0.11 (197) | 0.91 |
| Week 16 (OC N=81) | 20.12 | 4.63 | 20.51 | 4.74 | 0.55 (179) | 0.57 |
| Week 24 (OC N=87) | 20.58 | 5.21 | 20.83 | 5.04 | 0.33 (185) | 0.73 |
| ADAS Cog | ||||||
| Baseline (OC N=95) | 48.93 | 8.72 | 48.93 | 8.12 | 0.00 (193) | 1.00 |
| Week 16 (OC N=75) | 50.42 | 9.06 | 50.21 | 9.21 | −0.15 (173) | 0.88 |
| Week 24 (OC N=81) | 51.25 | 9.47 | 50.72 | 9.59 | −.35 (179) | 0.72 |
| ADL | ||||||
| Baseline (OC = 100) | 61.19 | 10.26 | 61.19 | 10.26 | – | – |
| Week 16 (N= 81) | 60.39 | 11.42 | 60.26 | 11.93 | 0.07 (179) | 0.94 |
| Week 24 (N= 85) | 61.02 | 10.96 | 60.43 | 11.58 | 0.35 (183) | 0.73 |
Abbreviations: OC, observed cases; ITT-LOCF, intent to treat-last observation carried forward sample; MMSE, Mini-Mental State Examination; ADAS-Cog, Alzheimer’s disease Assessment Scale-Cognitive subscale; ADL, activities of daily living.