Table 4.
Multivariate analyses.
| Risk factors for 10-year pouchitis | ||||
|---|---|---|---|---|
| Univariate [HR and CI] | p value | Multivariate [HR and CI] | p value | |
| Clinical factors | ||||
| Female | 0.914 [0.579–1.445] | 0.701 | ||
| Diagnosis IBDU [ref: UC] | 2.455 [1.258–4.788] | 0.008 | 2.544 [1.304–4.963] | 0.006 |
| PSC | 1.417 [0.445–4.512] | 0.556 | ||
| Smoking [ref: no] | 0.554 | |||
| Previously | 1.322 [0.794–2.202 | |||
| Yes | 1.178 [0.513–2.615] | |||
| Complications after STC | 0.980 [0.563–1.706] | 0.944 | ||
| UC location [ref: right-sided] | 0.958 | |||
| Left-sided | 0.833 [0.288–2.413] | |||
| Pancolitis | 0.757 [0.262–2.189] | |||
| Toxic megacolon | 0.833 [0.268–2.585] | |||
| Rectal stump therapy before IPAA | 0.203 [0.660–2.191] | 0.547 | ||
| Systemic steroid useage before IPAA | 2.725 [1.352–5.492] | 0.005 | - | |
| Preoperative medication, any | 1.001 [0.982–1.021] | 0.891 | ||
| Anastomotic leakage | 0.982 [0.450–2.141] | 0.963 | ||
| Actively inflamed distal rectal stump | 2.523 [1.094–5.815] | 0.030 | 2.592 [1.124–5.978] | 0.025 |
| Diversion proctitis distal rectal stump | 1.078 [0.581–2.002] | 0.812 | ||
UC, ulcerative colitis; IBDU, inflammatory bowel disease unclassified; STC, subtotal colectomy; IPAA, ileal pouch-anal anastomosis; PSC, primary sclerosing cholangitis; HR, hazard ratio; CI, confidence interval.