Table 4.
Adjusted Time Ratios for Months to Events in the Continuum of Care by Cluster Growth Accounting for Genetic Heterogeneity (i.e., Membership in Same Transmission Cluster) Using Gamma Frailty Model
| Log Normal Gamma Shared Frailty | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| All Cases | Restricted to Cases With Follow-up Visit Within 1 year After Initial Linkage to Care | ||||||||
| Continuum Interval | Cluster Growth | TRa | 95% CI | θ2 | P | TRa | 95% CI | θb | P |
| Diagnosis to care | Low | Ref. | … | Ref. | … | ||||
| Medium | 0.98 | .85–1.14 | .848 | 0.98 | .84–1.14 | .770 | |||
| High | 0.91 | .77–1.07 | .252 | 0.93 | .79–1.09 | .355 | |||
| 0.11 | <.001 | 0.11 | <.001 | ||||||
| Care to suppression | Low | Ref. | … | Ref. | … | ||||
| Medium | 1.07 | .99–1.14 | .061 | 1.05 | .98–1.12 | .162 | |||
| High | 1.04 | .96–1.11 | .349 | 1.07 | .99–1.15 | .053 | |||
| 0.28 | <.001 | 0.28 | <.001 | ||||||
| Diagnosis to suppression | Low | Ref. | … | Ref. | … | ||||
| Medium | 1.04 | .97–1.11 | .229 | 1.02 | .96–1.09 | .473 | |||
| High | 0.99 | .92–1.07 | .873 | 1.02 | .95–1.10 | .519 | |||
| 0.22 | <.001 | 0.25 | <.001 | ||||||
| Suppression to rebound | Low | Ref. | … | Ref. | … | ||||
| Medium | 1.10 | .91–1.31 | .321 | 1.09 | .91–1.32 | .345 | |||
| High | 1.38 | 1.14–1.68 | .001 | 1.36 | 1.12–1.66 | .002 | |||
| 0.13 | .005 | 0.12 | .007 |
Abbreviations: CI, confidence interval; TR, time ratio.
aTime ratios > 1 indicate slower time to event, whereas time ratios < 1 indicates accelerated time to event.
bTheta is the variability of the gamma frailty across groups of cluster estimated from the data with a mean of 1.