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Model of the TPX2-mediated astral microtubule assembly pathway. Phosphorylation (P) of importin α at S62 by CDK1 switches its substrate preference from TPX2 to GM130. This switch enables GM130 on the mitotic Golgi clusters at the spindle poles to locally sequester importin α from TPX2 through direct competition. TPX2 is thereby relieved from inhibition, allowing it to bind to and activate Aurora A kinase to drive astral microtubule assembly and facilitate spindle orientation.
