Figure 4. Interaction Between Groups of Functional Hippocampal Connectivity and Hippocampal Glx:
An interaction between groups, hippocampal functional connectivity (FC), and hippocampal glutamate + glutamine (Glx) was seen in the orbitofrontal and entorhinal cortex. Z-scored FC beta weight values from the interaction region of interest ROI were extracted and plotted against hippocampal Glx levels. Healthy controls showed a positive correlation between hippocampal FC and Glx. Medication naïve first episode psychosis patients showed an opposite, negative correlation between FC and Glx.