Table 2:

Clusters of Significance

Analysis	Brain regions	Voxels in cluster	Hempishpere	Voxels in regiona	Peak coordinatesb			Peak t	P FDR c
					X	Y	Z
Hippocampal Connectivity
			Data Set 1
HC>FEP
Cluster 1		5696			−14	−22	−22	6.14
	Thalamus		B	511
	Parahippocampus		B	477
	Hippocampus		B	382
	Precuneus		B	362
	PCC		B	256
	mPFC/ACC (subcallosal)		B	193
	Fusiform Gyri		B	149
	Orbitofrontal Cortex		L	110
	Nucleus Accumbens		B	127
	Pallidum		B	78
	Putamen		B	86
FEP>HC
Cluster 1		8566			−22	−66	−4	−5.26
	Lateral Occipital Cortex		B	1855
	Occiptal Pole		B	1248
	Fusiform Gyri		B	787
	Lingual Gyri		B	638
	Middle Temporal Cortex		B	589
	Calcarine Sulcus		B	484
	Precuneus		B	269
	Angular Gyrus		L	222
	Fusiform Gyri		B	212
	Cuneus		B	201
	Supramarginal Gyri		B	74
			Data Set 2
HC>SZ
Cluster 1		2971			24	32	8	6.08
	Frontal Pole		R	149
	mPFC/ACC (subcallosal)		B	127
SZ>HC
Cluster 1		2608			−44	−84	−4	−7.60
	Occiptial Pole		B	858
	Lateral Occiptal Cortex		B	802
	Lingual Gyrus		B	156
	Precuneus		B	127
	Superior Parietal Cortex		L	102
Cluster 2		1750			−44	−52	−30	−5.37
	Inferior Temporal Cortex		L	98
Cluster 3		1601			32	−64	44	−4.82
	Lateral Occipital Cortex		R	897
	Angular Gyrus		R	201
	Supramarginal Gyrus		R	174
	Superior Parietal Cortex		R	151
Cluster 4		1493			24	−12	−4	−4.71
	Thalamus		R	300
	Hippocampus		R	113
	Putamen		R	100
	Lingual Gyrus		R	89
Cluster 5		1237			6	−22	30	−4.32
	PCC		B	656
Hippocampal Connectivity and Glutamate
Group Interaction
Cluster 1		3129			8	22	−16	5.94
	Frontal Pole		B	561
	vmPFC		B	291
	mPFC/ACC (subcallosal)		B	199
	Putamen		B	134
	Parahippocampus		L	98
	Orbitofrontal Cortex		B	77
	Caudate		B	52

Abbreviations: HC, healthy controls; FEP first episode psychosis patients; SZ unmedicated patients with schizophrenia; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex; mPFC, medial prefrontal cortex; vmPFC, ventral medial prefrontal cortex; L, left; R, right; B, bilateral.

^aRegions with ≥ 50 voxels were included in the table.

^bReported in Montreal Neurological Institute coordinates (X, Y and Z).

^cAll comparisons were FDR-corrected (P_FDR ≤ .05).