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. 2021 Feb 11;15(2):e0009125. doi: 10.1371/journal.pntd.0009125

Fig 2. Clinical observation scores of NHPs challenged with aerosolized B. pseudomallei.

Fig 2

(A) RM and (B) AGM response to B. pseudomallei HBPUB10134a; AGM response to (C) MSHR5855 and (D) K96243. The scoring parameters were appearance (normal = 0; fixed gaze = 1; abnormal postural changes = 2); respiratory rate (normal 16–40 breaths per min (bpm) = 0; >40 bpm = 1; abdominal breathing = 2); natural behavior (normal/baseline observation = 0; minor changes, less interaction = 1; less mobile and alert or holding onto cage = 2; no interaction, restless, anxious or still = 3); provoked behavior (normal = 0; subdued but responds to stimulation = 1; subdued even to stimulation = 2; unresponsive to gentle prodding = 3). The clinical observation scores are subjective measurements of disease severity based on the above observable parameters, including respiratory rates. Each point indicates an animal’s observed clinical score.