Fig 8.

Serum levels of (A) IgG and (B) IgM in NHPs aerosolized with B. pseudomallei HBPUB10134a, K96243 and MSHR5855. Following exposure to HBPUB10134a, the 5 AGM euthanized from day 5 to 13 had terminal GM (GSD) IgG and IgM titers of 20,950(2.67) and 4,314 (2.18), respectively. The 5 AGM exposed to K96243 and euthanized on days 4 to 43 had terminal IgG and IgM titers of 33,355 (12.38) and 7,651 (7.01), respectively, and the 5 AGM exposed to MSHR5855 and euthanized on days 8 to 43 had IgG and IgM titers of 172,355 (1.14) and 46,661 (1.62). By contrast, the 5 RM euthanized from day 13 to 47 had terminal IgG and IgM titers of 4,940,009 (2.60) and 3,964,462 (1.05), respectively. The AGM groups were each significantly different from RMs exposed to HBPUB10134a, for both IgG and IgM, by t-test (p < 0.05).