Table 1. Chemistry and other clinical manifestation of inhalation melioidosis.
| HBPUB1034a | K96243 | MSHR5855 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| AGM | RM | AGM | AGM | ||||||
| n | Mean(SEM) | n | Mean(SEM) | n | Mean(SEM) | n | Mean(SEM) | ||
| AST | Baseline | 5 | 59.4 (4.94) | 5 | 33.2 (2.78) | 5 | 50.2 (3.99) | 5 | 45.4 (6.87) |
| (U/L) | Day 4 | 5 | 77.4 (10.78) | 5 | 42.8 (9.53) | 5 | 91.2 (16.13) | 5 | 44.4 (6.95) |
| Terminal | 5 | 250.0 (61.72) * | 5 | 29.8 (6.91) | 4 | 120.3 (58.69) | 3 | 40.0 (5.51) | |
| ALP | Baseline | 5 | 80.0 (11.45) | 5 | 167.2 (14.33) | 5 | 91.8 (23.14) | 5 | 79.2 (19.46) |
| (U/L) | Day 4 | 5 | 178.4 (17.01) * | 5 | 244.8 (43.59) | 5 | 129.0 (24.35) | 5 | 97.6 (8.91) |
| Terminal | 5 | 238.6 (81.06) | 5 | 545.6 (107.27) * | 4 | 334.0 (182.36) | 3 | 113.3 (24.48) | |
| LDH | Baseline | NDa ND | 4 | 255.8 (33.13) | 5 | 233.4 (7.55) | |||
| (U/L) | Day 4 | 5 | 2522.6 (542.95) | 5 | 1838.8 (461.47) | 4 | 710.3 (155.23) | 5 | 256.0 (15.50) |
| Terminal | 3 | 4684.0 (1231.66) | 5 | 1174.4 (271.74) | 3 | 773.0 (227.00) | 3 | 203.3 (21.11) | |
| BUN | Baseline | 5 | 18.8 (3.41) | 5 | 13.8 (0.86) | 5 | 16.2 (2.35) | 5 | 15.4 (1.60) |
| (mg/dL) | Day 4 | ND ND | 5 | 26.8 (10.30) | 5 | 11.8 (2.13) | |||
| Terminal | 2 | 64.5 (14.50) | 1 | 36.0 (.) | 4 | 32.8 (12.71) | 3 | 5.7 (0.88) * | |
| CRP | Baseline | 5 | 8.8 (1.36) | 5 | 4.4 (0.24) | 5 | 5.0 (0.00) | 5 | 5.0 (0.00) |
| (mg/L) | Day 4 | 3 | 33.4 (12.82) | 1 | 73.0 (.) | 5 | 72.9 (20.85) | 5 | 23.3 (3.91) |
| Terminal | ND | 5 | 28.5 (13.63) | 3 | 86.3 (30.48) | 3 | 5.0 (0.00) | ||
*indicates significant change from baseline by Welch’s t-test (P < 0.05).
aND, not determined. Standard reference range for LDH was 402–1364 U/L.