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. 2021 Jan 20;223(4):645–654. doi: 10.1093/infdis/jiab025

Figure 1.

Figure 1.

A, Multifocal pneumonia with acute bilateral dense airspace consolidations (colored arrows) on chest radiograph (left panel) and noncontiguous chest computed tomographic images (right panel). B, CD4+ and CD8+ T cells in healthy controls (upper panels) and in the proband (lower panels) using fluorescent-conjugated antibodies targeting 2 different epitopes on the extracellular domain D1 (RPA-T4) and D3 (SK3) of CD4. C, CD14- and CD16-expressing monocytes in a healthy control (left upper panel) and in the proband (left lower panel). Distribution of fluorescence intensity of CD4 staining in permeabilized monocytes from a healthy control (cyan histogram), proband (red histogram), and isotype control (gray histogram). D, Gating on CD3+ lymphocytes, surface CD4, and intracellular HIV-1 p24 expression in positively selected CD4+ T cells of a healthy control and unfractionated T cells of the proband upon anti-CD3/CD28 stimulation and HIV-1SF162 infection (healthy controls, upper panels; proband, lower panels). The left panels represent mock infection while the right panels represent HIV-1SF162 infection (healthy controls, upper panels; proband, lower panels). Abbreviations: FMO, fluorescence minus one; HC, healthy controls; HIV-1, human immunodeficiency virus type 1; Pt, proband.