Figure 1.

Hypoxia reduced chemosensitivity of bladder cancer cells to cisplatin. (a) Viability of bladder cancer cells was measured after treatment with graded concentrations of cisplatin at 12, 24, and 48 h. (b) Cell viability was further observed after treatment with 2.5 and 5.0 μm cisplatin under normoxia. (c) BIU-87 cancer cells were cultured under hypoxic conditions with different concentrations of cisplatin for 12, 24, and 48 h. (d) Viability of cells incubated with cisplatin was reversed under hypoxia compared with that under normoxia.