Table 2.
The significant pathway enrichment analysis of upregulated DEGs
| Category | Term | P value | Genes |
|---|---|---|---|
| KEGG | hsa04110: cell cycle | 1.78E−02 | HDAC1, CDKN2C, CDC25A, ATM |
| KEGG | hsa04910: insulin signaling pathway | 2.36E−02 | PPP1R3E, PRKAR2A, PRKCI, PIK3R3 |
| KEGG | hsa04390: hippo signaling pathway | 2.97E−02 | PPP2R1B, TEAD4, PRKCI, LEF1 |
| KEGG | hsa05202: transcriptional misregulation in cancer | 3.84E−02 | HDAC1, CDKN2C, BCL6, ATM |
| REACTOME | R-HSA-113510: E2F mediated regulation of DNA replication | 2.85E−03 | DHFR, RRM2, CDC25A |
| REACTOME | R-HSA-69205: G1/S-specific transcription | 2.85E−03 | DHFR, RRM2, CDC25A |
| REACTOME | R-HSA-1538133: G0 and early G1 | 6.14E−03 | RBBP4, HDAC1, CDC25A |