Fig. 5.

Network of transcriptional NR1I3-mediated response elicited by pesticides (here shown: IMZ) in rat liver, as computed with Ingenuity Pathway Analysis software. Continuous lines indicate direct functional relationships, dashed lines indicate indirect relationships (i.e., do not require physical contact between the two molecules, as defined by IPA). Network nodes are labeled with the gene name and the functional classification of genes is denoted by their different shapes. The human genes CYP2B6, CYP2C19, CYP3A5, GSTA5 and GSTM5 correspond to the rat genes Cyp2b2, Cyp2b6, Cyp3a23/3a1, Gsta2, and Gstm1, respectively