Table 2.

Top ten differentially regulated genes (fold change; q < 0.05) after treatment with compounds alone and in mixtures

	Gene	Function	THI	IMZ	CTD	THI + IMZ	THI + CTD	IMZ + CTD
Up-regulation	Abcc3	Transporter	3.67	3.28	2.94	3.88	3.95	2.37
	Aldh1a1	Enzyme	2.77	2.31	2.55	2.75	3.14	2.09
	Cyp2b2	Enzyme	3.29	2.82	2.82	3.11	3.45	2.01
	Cyp3a23/3a1	Enzyme	2.60	2.82	1.59	2.41	2.47	1.78
	Mme	Enzyme	2.97	2.59	3.43	2.46	4.35	2.70
Down-regulation	Cyp7a1	Enzyme	− 1.80	− 1.18*	− 1.51	− 1.89	− 1.50	− 1.55
	Eln	Other	− 1.97	− 2.08	− 1.80	− 2.04	− 1.91	− 1.79
	Ky	Enzyme	− 2.41	− 1.65	− 3.21	− 2.32	− 2.89	− 1.65
	Megf11	Other	− 2.37	− 2.14	− 3.18	− 2.26	− 2.87	− 2.87
	Slc6a1	Transporter	− 1.77	− 1.37*	− 1.96	− 1.80	− 1.93	− 1.63

The asterisk indicates non-significant fold change