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Internalization of a redox-sensitive nanocarrier, cleavage of disulfide linker and drug release inside cells. Disulfide-linked nanocarrier is stable outside the tumor microenvironment with low level of GSH. However, the disulfide bond of this nanocarrier is reduced to thiol groups after endocytosis inside the tumor cell with high level of GSH resulting in the dissociation of the nanostructure and release of the encapsulated drugs. Reproduced with permission [117].
