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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Jan 14;41(3):1167–1178. doi: 10.1161/ATVBAHA.120.315369

Figure 1: Genetic loss of function in Bcl-xL decreases platelets in diabetic Ldlr+/− mice.

Figure 1:

A) Experimental overview: Ldlr+/− mice were transplanted with BM from Bcl-xPLT20 mice or littermate controls (WT), made diabetic with STZ and fed a WTD. B) Blood glucose and C) plasma cholesterol levels at the end of the study. D) Circulating platelets, E) leukocytes and F) BM haematopoietic stem and progenitor cells were quantified by flow cytometry. Data are presented mean ± SEM and analyzed using a Student’s unpaired t-test, biological replicates of n=6 & 7/group; *p<0.05, ***p<0.001, ****p<0.0001.