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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Mitochondrion. 2021 Jan 21;57:192–204. doi: 10.1016/j.mito.2021.01.003

Figure 3. Ru360 treatment on the ipsilateral hemisphere TBI metabolome.

Figure 3.

A) Volcano plot showing fold changes (FC) on the x-axis and FDR adjusted p-values on the y-axis. Black vertical and horizontal lines reflect the threshold criteria (FC=1.0 and p<0.05). Green and red dots represent metabolites which significantly increased or decreased after Ru360 treatment respectively. 8% of the metabolites significantly changed between TBI+Ru360 treated (n=6) and control TBI animals (n=6). Table on the right indicates significantly changed metabolites as numbered in the volcano plot on the left panel. B) PLS-DA 2D scores plot and C) PLS-DA 3D scores plot respectively, indicating a complete class separation between Ru360 treated TBI (green dots) versus control TBI animals (red dots) with a tight clustering of the TBI metabolome across the Ru360 treated animals.