Figure 4. Pathway analysis of control versus Ru360 treatment on the ipsilateral hemisphere.

A) Left-panel: Pathway analysis using MetPA with node colors indicating uncorrected p-values and node size the pathway impact values. Right-panel: Table showing significantly changed metabolic pathways with a threshold of p<0.05 for the corrected Holm p-value. B) Left-panel: MSEA results with y-axis indicating the significantly different metabolite sets based on a threshold of p<0.05 for the Holm p-value and color scaled to the corrected Holm p-value and x-axis indicating the respective fold enrichment. Right-panel: Table showing affected pathways relevant to the significantly enriched metabolite sets determined by MSEA.