Figure 8. Schematic of biochemical pathways and metabolite changes.

Metabolites affected by TBI when compared to sham from our prior study on this TBI model (Chitturi, Li et al. 2018) and Ru360 treatment vs no drug effects on the TBI brain across the ipsilateral and contralateral hemispheres. Arrow directions indicate significant increase (↑) or decrease (↓) in metabolites (P<0.05; FDR corrected). No significant change was observed in any metabolite across the contralateral hemisphere after TBI when compared to contralateral sham (Chitturi, Li et al. 2018).