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. Author manuscript; available in PMC: 2022 Jan 10.
Published in final edited form as: J Control Release. 2020 Dec 5;329:434–444. doi: 10.1016/j.jconrel.2020.12.003

Figure 3. Physico-chemical properties and in vitro drug release study of D-Triptolide conjugate.

Figure 3.

(A) Hydrodynamic diameter of D-triptolide conjugate measured in triplicates by dynamic light scattering; (B) Zeta potential distribution of D-Triptolide showing a near neutral zeta potential; (C) Aqueous solubility comparison of D-triptolide to free triptolide showing triptolide sparingly soluble in water at 1mg/mL while D-triptolide completely soluble in water at 50mg/mL (9mg/mL triptolide equivalent) demonstrating enhanced solubility of triptolide resulting from dendrimer conjugation; and (D) In vitro drug release study of D-Triptolide at extracellular plasma conditions (pH 7.4) and intracellular conditions (pH 5.5 plus esterases).