Table 2.
Association of eGFR Slope With 3 Measures of Baseline Obesity by Sex and Race
| White (n = 10,222) |
Black (n = 3,274) |
|||
|---|---|---|---|---|
| Men (n = 4,802) | Women (n = 5,420) | Men (n = 1,270) | Women (n = 2,004) | |
| BMI, kg/m2 | 27.23 ± 3.86 | 26.33 ± 5.09 | 27.28 ± 4.53 | 30.29 ± 6.36 |
| eGFR slope per 1-SD greater BMIa,b | ||||
| Model 1c,d | 0.09 (−0.18 to 0.36) | −0.91 (−1.15 to −0.67)e | −0.70 (−1.54 to 0.14) | −1.35 (−1.92 to −0.78)e |
| Model 2c,d | 0.52 (0.23 to 0.80)e | −0.27 (−0.53 to −0.02)f | 0.03 (−0.85 to 0.91) | −0.85 (−1.45 to −0.25)g |
| WHR | 0.97 ± 0.05 | 0.89 ± 0.08 | 0.94 ± 0.05 | 0.90 ± 0.08 |
| eGFR slope per 1-SD greater WHRa,b | ||||
| Model 1 c,d | −0.25 (−0.50 to 0.005) | −0.82 (−1.06 to −0.58)e | −1.60 (−2.42 to −0.78)e | −1.50 (−2.05 to −0.95)e |
| Model 2c,d | 0.15 (−0.13 to 0.43) | −0.16 (−0.41 to 0.09) | −0.40 (−1.32 to 0.52) | −1.07 (−1.68 to −0.46)e |
| Predicted percent fat, % | 28.49 ± 3.88 | 39.99 ± 4.92 | 26.31 ± 4.65 | 41.83 ± 5.99 |
| eGFR slope per 1-SD greater predicted % fata,b | ||||
| Model 1 c,d | −0.14 (−0.41 to 0.13) | −1.02 (−1.26 to −0.78)e | −1.24 (−2.08 to −0.40)g | −1.43 (−2.00 to −0.86)e |
| Model 2c,d | 0.30 (0.02 to 0.59)f | −0.32 (−0.58 to −0.06)f | −0.26 (−1.17 to 0.65) | −0.90 (−1.5 to −0.29)g |
Note: The unit for eGFR slope was mL/min/1.73 m2 per decade; all such values given as estimate (95% CI).
Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; SD, standard deviation; WHR, waist-to-hip ratio.
Centered at median of each race-sex group.
In an overall unadjusted model combining sex-race groups, P < 0.001 for all obesity measurements for interaction between sex-race and the association of eGFR decline with baseline obesity.
Model 1 adjusted for age (continuous), center (categorical), current smoker (yes/no), and prevalent coronary heart disease (yes/no) at baseline; model 2 additionally adjusted for hypertension medication (yes/no), systolic blood pressure (continuous), total cholesterol level (continuous), high-density lipoprotein cholesterol level (continuous), triglyceride level (continuous, log transformed), education level (high school graduate/not), and annual family income (categorical) at baseline.
Black participants in the Minnesota and Washington County centers were excluded in the model because of small numbers.
P < 0.001.
P < 0.05.
P < 0.01.