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. Author manuscript; available in PMC: 2022 Jan 10.
Published in final edited form as: J Control Release. 2020 Oct 7;329:774–781. doi: 10.1016/j.jconrel.2020.10.011

Figure 2: The presence of APA at time of PEG-liposome dosing reduces induction of APA.

Figure 2:

(A) Naïve mice were administered monoclonal anti-PEG IgG (“APA”; n=4) or PBS (“PBS”; n=8) 24 h prior to infusion of PEG-liposomes. Then, 7 days later, blood was collected to quantify APA. (B) Naïve mice (n=4) were treated at Day 0 and blood was collected at Day 7 for the measurement of APA induced by the various treatments. Comparisons across group averages were conducted using unpaired t-tests, with *,**, and *** representing p<0.05, 0.01, and 0.001, respectively. NS; no significant difference.