. Author manuscript; available in PMC: 2022 Mar 1.

Published in final edited form as: Psychoneuroendocrinology. 2021 Jan 14;125:105132. doi: 10.1016/j.psyneuen.2021.105132

Table 3.

Associations of change in depression with changes in alpha diversity and richness and gut permeability markers.

Outcome	Estimate (SE)	95% CI	p-value
Shannon diversity change	−0.010 (0.0043)	−0.019, −0.0016	0.02
Richness change	−0.59 (0.21)	−1.00, −0.18	0.005
LBP change	19.8 (16.0)	−11.7, 51.3	0.22
sCD14 change	1.8 (2.8)	−3.8, 7.4	0.52
LBP to sCD14 change	0.011 (0.0097)	−0.0081, 0.030	0.26

Change defined as visit 2 minus visit 1

P-values from separate linear mixed effects models adjusting for age, gender, BMI, antidepressant usage, baseline outcome level, and baseline depression.

Sample sizes: Shannon diversity, Richness, n=162; LBP, sCD14, and LBP to sCD14 ratio, n=154.